St Louis, Missouri, United States (On-Site)
·
Posted 1 day ago
$95k–$150k / yr
Job FunctionOrganic
Job TypeFull-Time
Job DurationIndefinite
Min EducationBA/BS/Undergraduate
Min Experience2-3 Years
Required TravelNone
Salary$95,000.00 - $150,000.00
Salary - TypeYearly Salary
Senior Radiochemist
Senior Radiochemist
About this role
Design and execute multi-step organic syntheses of Carbon-14 and Tritium labeled compounds
Develop and optimize synthetic routes for custom client projects
Purify and isolate synthetic intermediates and final radiolabeled compounds using HPLC, flash chromatography, solid-phase extraction, crystallization, and liquid-liquid extraction
Identify and characterize synthesized compounds using HPLC, mass spectrometry (MS), nuclear magnetic resonance (NMR), and infrared spectroscopy (IR); assess chemical and radiochemical quality
Troubleshoot difficult synthetic and purification challenges
Maintain accurate laboratory notebooks, experimental records, and project documentation
Prepare technical summaries and supporting documentation
Work safely and effectively with radioactive materials in accordance with established procedures
Collaborate with chemists, quality personnel, and management
Manage multiple custom synthesis projects while maintaining quality and project timelines
Contribute scientific expertise to the continued development of ARC's radiochemistry capabilities
Key Requirements
B.S., M.S., or Ph.D. in Chemistry, Organic Chemistry, Radiochemistry, or a closely related discipline
Significant hands-on experience in multi-step organic synthesis, preferably involving Carbon-14 and Tritium labeled compounds
Demonstrated ability to independently execute multi-step synthetic chemistry
Strong practical knowledge of purification and isolation methods, including HPLC, flash chromatography, solid-phase extraction, crystallization, and liquid-liquid extraction
Experience purifying both reaction intermediates and final compounds, and confirming compound identity through complementary analytical methods
Excellent laboratory documentation and organizational skills
Strong troubleshooting and problem-solving abilities
Ability to work both independently and collaboratively
PREFERRED QUALIFICATIONS
Direct experience with Carbon-14 and/or Tritium radiochemistry and multi-step labeled-compound synthesis
Experience with custom synthesis or contract research projects
Hands-on experience with HPLC, flash chromatography, solid-phase extraction, and analytical characterization by MS, NMR, and IR; radio-HPLC and radio-TLC are additional advantages
Experience working under established radiation-safety procedures
Experience developing synthetic routes from literature research through final compound delivery
